1. Chemically Modified DNAzyme with Enhanced Activity for Sensitive MicroRNA Imaging in Live Cells

Jiawen Chen, Juan Wang, Jiahuan Wang, Fulong Wang, Wenyu Cheng, Siqi Chen, Rui Mo and Hanyang Yu*

MOLECULES. 2026;31(8):1271.

https://doi.org/10.3390/molecules31081271

2. Sanger Sequencing of Xeno-Nucleic Acid

Yueyao Wang^#, Ze Zhang^#, Lekang Chen^#, Jing Zhu, Shunfu Qin, Dongying Wei, Jibao Zhang, Feng Han, Fulong Wang, Qi Lin, Rui Fan, Xintong Li, Hanyang Yu*

Angew. Chem. Int. Ed. 2026;65:e16617.

https://doi.org/10.1002/anie.202516617

3. Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer

Feng Xu^#, Jingtong Xu^#, Feng Han^#, Ke Wang, Fulong Wang, Hanyang Yu* and Xiaoxiang Guan*

J. Med. Chem. 2025;68(19):19971-19983.

https://doi.org/10.1021/acs.jmedchem.5c00492

4. A Threose Nucleic Acid (TNA) Enzyme Catalyzing Native 3'-5' Ligation of RNA

Juan Wang, Feng Han, Ye Zou, Mengqi Wang, Yao Wang, Jia-Yu Chen, and Hanyang Yu*

J. Am. Chem. Soc. 2025;147(21):18349-18358.

https://doi.org/10.1021/jacs.5c07235  

5. Spatially Preorganized Hybridization Chain Reaction for the Prompt Diagnosis of Inflammation

Bin Jia, Jingru Ge, Yuxuan Ma, Xiaolei Sun, Zhe Li*, Shuoxing Jiang*, and Hanyang Yu*

Angew. Chem. Int. Ed. 2025;e202421022.

https://doi.org/10.1002/anie.202421022

6. Chemoenzymatic Installation of Site-Specific Chemical Groups on DNA Enhances the Catalytic Activity

Ze Zhang^#, Wanqing Wei^#, Siqi Chen^#, Jintao Yang, Dongfan Song, Yinghan Chen, Zerun Zhao, Jiawen Chen, Fulong Wang, Jiahuan Wang, Zhe Li, Yong Liang*, and Hanyang Yu*

J. Am. Chem. Soc. 2024;146(10):7052-7062.

https://doi.org/10.1021/jacs.4c00484 

7. Enzymatic Synthesis of TNA Protects DNA Nanostructures

Bohe Qin^#, Qi Wang^#, Yuang Wang, Feng Han, Haiyan Wang, Shuoxing Jiang*, Hanyang Yu*

Angew. Chem. Int. Ed. 2024;63(13):e202317334.

https://doi.org/10.1002/anie.202317334

8. c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer

Xintong Li^#, Ze Zhang, Fangyan Gao, Yuxuan Ma, Dongying Wei, Zhangwei Lu, Siqi Chen, Mengqi Wang, Yueyao Wang, Kun Xu, Runtian Wang, Feng Xu, Jia-Yu Chen, Chengjun Zhu, Zhe Li, Hanyang Yu*, and Xiaoxiang Guan*

J. Am. Chem. Soc. 2023;145(16):9334.

https://doi.org/10.1021/jacs.3c02619

9. Selection of RNA-Cleaving TNA Enzymes for Cellular Mg²⁺ Imaging

Mingmei Gao^#, Dongying Wei^#, Siqi Chen, Bohe Qin, Yueyao Wang, Zhe Li, Hanyang Yu*

Chembiochem. 2023;24(4):e202200651.

https://doi.org/10.1002/cbic.202200651

10. A Nucleic Acid Sequence That is Catalytically Active in Both RNA and TNA Backbones

Dongying Wei^#, Yueyao Wang, Dongfan Song, Ze Zhang, Juan Wang, Jia-Yu Chen, Zhe Li, and Hanyang Yu*

ACS Synth Biol. 2022;11(11):3874.

https://pubs.acs.org/doi/full/10.1021/acssynbio.2c00479

11. DNA-catalysed alternative RNA splicing

Dongying Wei^#, Mingmei Gao, Jiajie Guo, Yueyao Wang, Xintong Li, Zhe Li*, Hanyang Yu*

Chem Commun (Camb). 2022;58(55):7698.

https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC00812B

12. Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer

Yao Wang^#，Yang Zhang^#，Peng-Chao Li^#，Jiajie Guo，Fan Huo，Jintao Yang，Ru Jia，Juan Wang，Qiju Huang，Dan Theodorescu*，Hanyang Yu*，Chao Yan*

Cancer Res. 2022; 82(6):1128.

https://aacrjournals.org/cancerres/article-abstract/82/6/1128/682057/Development-of-Novel-Aptamer-Based-Targeted?redirectedFrom=fulltext

13. An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination

Yueyao Wang^#, Yao Wang^#, Dongfan Song, Xin Sun, Zhe Li*, Jia-Yu Chen and Hanyang Yu* 

Nat Chem. 2022; 14(3):350.

https://www.nature.com/articles/s41557-021-00847-3

14. A Threose Nucleic Acid Enzyme with RNA Ligase Activity

Yao Wang^#, Yueyao Wang, Dongfan Song, Xin Sun, Ze Zhang, Xintong Li, Zhe Li, and Hanyang Yu*

J. Am. Chem. Soc. 2021;143(21):8154.

https://pubs.acs.org/doi/10.1021/jacs.1c02895

15. Selection of Threose Nucleic Acid Aptamers to Block PD-1/PD-L1 Interaction for Cancer Immunotherapy

Xintong Li^# , Zhe Li , Hanyang Yu*

Chem Commun (Camb).2020;56(93):14653.

https://doi.org/10.1039/D0CC06032A

16. Proteomic analysis of cisplatin- and oxaliplatin-induced phosphorylation in proteins bound to Pt-DNA adducts

Xin Yuan^#, Wanjun Zhang^#, Yafeng He, Jian Yuan, Dongfan Song, Hao Chen, Weijie Qin*, Xiaohong Qian, Hanyang Yu*, Zijian Guo*

Metallomics. 2020;12(11):1834.

https://academic.oup.com/metallomics/article/12/11/1834/6071930

17. Aptamer-Based Western Blot for Selective Protein Recognition

Yao Wang^#, Zhe Li, Hanyang Yu*

Front Chem. 2020;8:570528.

https://www.frontiersin.org/articles/10.3389/fchem.2020.570528/full

18. Direct sequencing of 2'-deoxy-2'-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS).

Shuanghong Yan^#, Xintong Li^#, Panke Zhang, Yuqin Wang, Hong-Yuan Chen, Shuo Huang, and Hanyang Yu*

Chem Sci. 2019;10(10):3110. 

https://pubs.rsc.org/en/content/articlelanding/2019/SC/C8SC05228J#!divAbstract

19. A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm. 

Yueyao Wang^#, Jintao Yang, Xin Yuan, Jin Cao, Jiacui Xu, John C. Chaput, Zhe Li* and Hanyang Yu*

Sci Rep. 2019;9(1):8224. 

https://www.nature.com/articles/s41598-019-44750-x

20. Self-Assembly of Large DNA Origami with Custom-Designed Scaffolds

Xiaoxing Chen^#, Qian Wang^#, Jin Peng, Qipeng Long, Hanyang Yu*, and Zhe Li*

ACS Appl. Mater. Interfaces. 2018; 10: 24344

https://pubs.acs.org/doi/10.1021/acsami.8b09222

21. An efficient and faithful in vitro replication system for threose nucleic acid

H. Yu^#, S. Zhang, M. Dunn, and J. C. Chaput*

J Am Chem Soc. 2013;135(9):3583.

https://pubs.acs.org/doi/10.1021/ja3118703

22. Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension

S. Zhang^#, H. Yu, and J. C. Chaput*

Curr Protoc Nucleic Acid Chem. 2013;Chapter 4:Unit 4.54.

https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/0471142700.nc0454s52

23. Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenito

H. Yu^#, S. Zhang^#, and J. C. Chaput*

Nat Chem. 2012;4(3):183.

https://www.nature.com/articles/nchem.1241

24. The emerging world of synthetic genetics

J. C. Chaput^#*, H. Yu, and S. Zhang

Chem Biol. 2012;19(11):1360.

https://www.sciencedirect.com/science/article/pii/S1074552112004127?via%3Dihub

25. Aptamers can discriminate alkaline proteins with high specificity

H. Yu^#, B. Jiang, and J. C. Chaput*

Chembiochem. 2011;12(17):2659. 

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201100252

26. Generating DNA synbodies from previously discovered peptides

R. Liu^#, B. Jiang, H. Yu, and J. C. Chaput*

Chembiochem. 2011;12(12):1813.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201100284